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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010132,
umls-concept:C0010453,
umls-concept:C0010531,
umls-concept:C0020663,
umls-concept:C0021753,
umls-concept:C0030685,
umls-concept:C0033634,
umls-concept:C0205263,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1963578
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pubmed:issue |
1
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pubmed:dateCreated |
1992-10-8
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pubmed:abstractText |
Interleukin-1 beta (IL-1 beta) induces a dose-dependent increase in the release of corticotropin-releasing factor-41 (CRF) from dispersed rat fetal hypothalamic cells in culture. This release of CRF could be inhibited by the protein kinase C inhibitor H-7, and by the protein kinase A inhibitor IP-20. This suggests that both protein kinase C and protein kinase A-dependent pathways are involved in the response of CRF to IL-1 beta. Dexamethasone also blocked the CRF response to IL-1 beta, indicating that activated glucocorticoid receptors can inhibit the response of CRF to IL-1 beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-55
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1517398-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:1517398-Animals,
pubmed-meshheading:1517398-Cells, Cultured,
pubmed-meshheading:1517398-Corticotropin-Releasing Hormone,
pubmed-meshheading:1517398-Dexamethasone,
pubmed-meshheading:1517398-Hypothalamus,
pubmed-meshheading:1517398-Interleukin-1,
pubmed-meshheading:1517398-Isoquinolines,
pubmed-meshheading:1517398-Osmolar Concentration,
pubmed-meshheading:1517398-Piperazines,
pubmed-meshheading:1517398-Protein Kinase C,
pubmed-meshheading:1517398-Protein Kinase Inhibitors,
pubmed-meshheading:1517398-Protein Kinases,
pubmed-meshheading:1517398-Time Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Interleukin-1 beta induces corticotropin-releasing factor-41 release from cultured hypothalamic cells through protein kinase C and cAMP-dependent protein kinase pathways.
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pubmed:affiliation |
Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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