Linked Life Data

15165736

Source:http://linkedlifedata.com/resource/pubmed/id/15165736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-5-28
pubmed:abstractText
Ionotropic glutamate receptors are ligand-gated ion channels that mediate rapid information transfer at most excitatory synapses in the brain. Crystal structures are now available for the ligand-binding domain, but the structure of the ion channel itself remains unknown. The core of the ion channel shares structural features with an inverted K(+) channel. In detail, however, differences are emerging. Most notable in the glutamate receptor ion channel are distinct structural and functional properties of a major pore-lining domain, the requirement of an additional transmembrane segment (M4), and twofold rather than fourfold symmetry. Together with ligand-binding domain structures and kinetic experiments, these findings have started to define the basic principles of channel gating in glutamate receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
321-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Structure and gating of the glutamate receptor ion channel.
pubmed:affiliation
Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794-5230, USA. lwollmuth@notes1.cc.sunysb.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't