|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2004-5-27
|
|
pubmed:abstractText |
Structure-activity relationships were investigated on a novel series of tricyclic dihydropyridine-containing K(ATP) openers. This diverse group of analogues, comprising a variety of heterocyclic rings fused to the dihydropyridine nucleus, was designed to determine the influence on activity of hydrogen-bond-donating and -accepting groups and their stereochemical disposition. Compounds were evaluated for K(ATP) activity in guinea pig bladder cells using a fluorescence-based membrane potential assay and in a pig bladder strip assay. The inhibition of spontaneous bladder contractions in vitro was also examined for a subset of compounds. All compounds studied showed greater potency to inhibit spontaneous bladder contractions relative to their potencies to inhibit contractions elicited by electrical stimulation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
pubmed-author:AgriosKonstantinos AKA,
pubmed-author:AltenbachRobert JRJ,
pubmed-author:BucknerSteven ASA,
pubmed-author:CarrollWilliam AWA,
pubmed-author:ChenYiyuanY,
pubmed-author:CoghlanMichael JMJ,
pubmed-author:DazaAnthony VAV,
pubmed-author:DrizinIreneI,
pubmed-author:GopalakrishnanMuraliM,
pubmed-author:HenryRodger FRF,
pubmed-author:KortMichael EME,
pubmed-author:KymPhilip RPR,
pubmed-author:MilicicIvanI,
pubmed-author:SmithJamie CJC,
pubmed-author:SullivanJames PJP,
pubmed-author:TangRuiR,
pubmed-author:TurnerSean CSC,
pubmed-author:WhiteakerKristi LKL,
pubmed-author:ZhangHenryH
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3180-92
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15163197-Adenosine Triphosphate,
pubmed-meshheading:15163197-Animals,
pubmed-meshheading:15163197-Dihydropyridines,
pubmed-meshheading:15163197-Electric Stimulation,
pubmed-meshheading:15163197-Guinea Pigs,
pubmed-meshheading:15163197-Hemodynamics,
pubmed-meshheading:15163197-Heterocyclic Compounds, 3-Ring,
pubmed-meshheading:15163197-Hydrogen Bonding,
pubmed-meshheading:15163197-Membrane Potentials,
pubmed-meshheading:15163197-Muscle, Smooth,
pubmed-meshheading:15163197-Muscle Contraction,
pubmed-meshheading:15163197-Potassium Channels,
pubmed-meshheading:15163197-Stereoisomerism,
pubmed-meshheading:15163197-Structure-Activity Relationship,
pubmed-meshheading:15163197-Swine,
pubmed-meshheading:15163197-Urinary Bladder,
pubmed-meshheading:15163197-Urodynamics
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.
|
|
pubmed:affiliation |
Neuroscience Research, R4PM, AP10, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. william.a.carroll@abbott.com
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
