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pubmed-article:15161853pubmed:abstractTextPrior work has shown that autoimmune uveoretinitis develops spontaneously in CD25(+)CD4(+) regulatory T-cell-depleted mice (Tr-depleted mice). In this study, the generation of autoantibodies and autoreactive T-cells specific to retinal antigens was examined in Tr-depleted mice with uveoretinitis, and the pathogenic and immunogenic abilities of the autoreactive T cells were evaluated.lld:pubmed
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pubmed-article:15161853pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15161853pubmed:articleTitleImmune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice.lld:pubmed
pubmed-article:15161853pubmed:affiliationDepartment of Ophthalmology, Tokyo Medical University, Tokyo, Japan. takeuchi@tokyo-med.ac.jplld:pubmed
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pubmed-article:15161853pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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