Source:http://linkedlifedata.com/resource/pubmed/id/15159299
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0006142,
umls-concept:C0006826,
umls-concept:C0012155,
umls-concept:C0023981,
umls-concept:C0042036,
umls-concept:C0071011,
umls-concept:C0080103,
umls-concept:C0086045,
umls-concept:C0229671,
umls-concept:C0239307,
umls-concept:C0329155,
umls-concept:C0596244,
umls-concept:C1261322,
umls-concept:C1512806
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-5-25
|
| pubmed:abstractText |
Subjects of this study consisted of 333 women (aged 45-75 years) drawn from a large United Kingdom prospective study of diet and cancer, the European Prospective Investigation of Cancer and Nutrition-Norfolk study. Using newly developed gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry methods incorporating triply (13)C-labeled standards, seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in 114 spot urines and 97 available serum samples from women who later developed breast cancer. Results were compared with those from 219 urines and 187 serum samples from healthy controls matched by age and date of recruitment. Dietary levels were low, but even so, mean serum levels of phytoestrogens were up to 600 times greater than postmenopausal estradiol levels. Phytoestrogen concentrations in spot urine (adjusted for urinary creatinine) correlated strongly with that in serum, with Pearson correlation coefficients > 0.8. There were significant relationships (P < 0.02) between both urinary and serum concentrations of isoflavones across increasing tertiles of dietary intakes. Urinary enterodiol and enterolactone and serum enterolactone were significantly correlated with dietary fiber intake (r = 0.13-0.29). Exposure to all isoflavones was associated with increased breast cancer risk, significantly so for equol and daidzein. For a doubling of levels, odds ratios increased by 20-45% [log(2) odds ratio = 1.34 (1.06-1.70; P = 0.013) for urine equol, 1.46 (1.05-2.02; P = 0.024) for serum equol, and 1.22 (1.01-1.48; P = 0.044) for serum daidzein]. These estimates of risk are similar to those established for estrogens and androgens in postmenopausal breast cancer but need confirmation in larger studies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1055-9965
|
| pubmed:author |
pubmed-author:BinghamSheila ASA,
pubmed-author:BottingNigel PNP,
pubmed-author:DayNick ENE,
pubmed-author:DowsettMitchM,
pubmed-author:GracePhilip BPB,
pubmed-author:KhawKay-TeeKT,
pubmed-author:LowYen-LingYL,
pubmed-author:LubenRobert NRN,
pubmed-author:MulliganAngela AAA,
pubmed-author:TaylorJames IJI,
pubmed-author:WarehamNick JNJ,
pubmed-author:WelchAilsa AAA
|
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
698-708
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15159299-Adult,
pubmed-meshheading:15159299-Aged,
pubmed-meshheading:15159299-Analysis of Variance,
pubmed-meshheading:15159299-Breast Neoplasms,
pubmed-meshheading:15159299-Case-Control Studies,
pubmed-meshheading:15159299-Diet,
pubmed-meshheading:15159299-Dietary Supplements,
pubmed-meshheading:15159299-Great Britain,
pubmed-meshheading:15159299-Humans,
pubmed-meshheading:15159299-Incidence,
pubmed-meshheading:15159299-Isoflavones,
pubmed-meshheading:15159299-Middle Aged,
pubmed-meshheading:15159299-Odds Ratio,
pubmed-meshheading:15159299-Phytoestrogens,
pubmed-meshheading:15159299-Plant Preparations,
pubmed-meshheading:15159299-Probability,
pubmed-meshheading:15159299-Prognosis,
pubmed-meshheading:15159299-Prospective Studies,
pubmed-meshheading:15159299-Reference Values,
pubmed-meshheading:15159299-Registries,
pubmed-meshheading:15159299-Risk Assessment,
pubmed-meshheading:15159299-Sensitivity and Specificity,
pubmed-meshheading:15159299-Tumor Markers, Biological
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk.
|
| pubmed:affiliation |
MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|