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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-5-25
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pubmed:abstractText |
T cell mediated response is involved in a protective immune response against experimental cysticercosis conferred by immunization with Taenia solium paramyosin (TPmy) to BALB/c mice. In this study, we analysed the TPmy amino acid sequence for predicted CD4+ T cells epitopes. Five different regions of this protein showed that the residues anchor to bind the I-Ad molecule, synthetic peptides containing these epitopes were evaluated for their ability to induce lymphoproliferative responses of spleen cells from TPmy immunized mice. Among them, Tp176 (amino acids 176-192 sequence DDLQRQMADANSAKSRL) was the immunodominant T cell epitope of TPmy. Delineation of this epitope should facilitate analysis of the role of CD4+ T cell response in experimental cysticercosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0141-9838
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15157028-Amino Acid Sequence,
pubmed-meshheading:15157028-Animals,
pubmed-meshheading:15157028-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15157028-Cell Division,
pubmed-meshheading:15157028-Cysticercosis,
pubmed-meshheading:15157028-Epitope Mapping,
pubmed-meshheading:15157028-Epitopes, T-Lymphocyte,
pubmed-meshheading:15157028-Female,
pubmed-meshheading:15157028-Histocompatibility Antigens Class II,
pubmed-meshheading:15157028-Immunodominant Epitopes,
pubmed-meshheading:15157028-Mice,
pubmed-meshheading:15157028-Mice, Inbred BALB C,
pubmed-meshheading:15157028-Molecular Sequence Data,
pubmed-meshheading:15157028-Peptide Fragments,
pubmed-meshheading:15157028-Taenia solium,
pubmed-meshheading:15157028-Tropomyosin
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pubmed:year |
2003
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pubmed:articleTitle |
Identification of CD4+ T cell epitopes of Taenia solium paramyosin.
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pubmed:affiliation |
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, D.F., México, DF.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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