|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-6-4
|
|
pubmed:abstractText |
The beta(2)-adrenergic receptor (ADRB2) is the most common adrenergic receptor in the lung, and associations between ADRB2 polymorphisms and intermediate phenotypes of asthma have been reported. Four missense polymorphisms (Arg16Gly, Gln27Glu, Val34Met, and Thr164Ile) and one polymorphism in the 5' leader cistron of the ADRB2 messenger RNA has been identified. In vitro studies have shown that these missense polymorphisms can affect ADRB2 function.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1018-2438
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2004 S. Karger AG, Basel
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
134
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
150-7
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15153795-Adolescent,
pubmed-meshheading:15153795-Adult,
pubmed-meshheading:15153795-Aged,
pubmed-meshheading:15153795-Asthma,
pubmed-meshheading:15153795-Child,
pubmed-meshheading:15153795-Child, Preschool,
pubmed-meshheading:15153795-Family Health,
pubmed-meshheading:15153795-Female,
pubmed-meshheading:15153795-Genetic Predisposition to Disease,
pubmed-meshheading:15153795-Genotype,
pubmed-meshheading:15153795-Humans,
pubmed-meshheading:15153795-Japan,
pubmed-meshheading:15153795-Linkage Disequilibrium,
pubmed-meshheading:15153795-Male,
pubmed-meshheading:15153795-Middle Aged,
pubmed-meshheading:15153795-Polymorphism, Genetic,
pubmed-meshheading:15153795-Receptors, Adrenergic, beta-2,
pubmed-meshheading:15153795-Sensitivity and Specificity,
pubmed-meshheading:15153795-Statistics as Topic
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis.
|
|
pubmed:affiliation |
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki 305-8575, Japan.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Meta-Analysis
|
