Source:http://linkedlifedata.com/resource/pubmed/id/15149646
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2004-5-19
|
| pubmed:abstractText |
A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3069-72
|
| pubmed:meshHeading |
pubmed-meshheading:15149646-Animals,
pubmed-meshheading:15149646-Anti-Bacterial Agents,
pubmed-meshheading:15149646-Drug Evaluation, Preclinical,
pubmed-meshheading:15149646-Female,
pubmed-meshheading:15149646-Isoxazoles,
pubmed-meshheading:15149646-Mice,
pubmed-meshheading:15149646-Microbial Sensitivity Tests,
pubmed-meshheading:15149646-Oxazolidinones
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones.
|
| pubmed:affiliation |
Antimicrobial Agents Research Team, Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LL C, 1000 Route 202, Raritan, NJ 08869, USA.
|
| pubmed:publicationType |
Journal Article
|