Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2004-5-19
pubmed:abstractText
A full account of the total syntheses of proteasome inhibitors TMC-95A and -B is provided. A key feature of the syntheses involved installation of a cis-propenylamide moiety by a thermal rearrangement of an alpha-silylallyl amide. The scope and mechanism of the enamide-forming reaction are discussed. Also provided are some preliminary results from SAR studies. It was found that simplified analogues can retain the full potency of proteasome inhibition.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-10805568, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-10814045, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-11410931, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-11493007, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-11514224, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-11529776, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-11927937, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-12529139, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-12708862, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-12794861, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-8087844, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-8811196, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-9148969, http://linkedlifedata.com/resource/pubmed/commentcorrection/15149232-9857172
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6347-55
pubmed:dateRevised
2010-12-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR.
pubmed:affiliation
Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't