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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-5-14
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pubmed:abstractText |
The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common primary mutation 90M at virological failure (conferring some resistance to all protease inhibitors [PIs]) was evaluated in 93 previously drug-naive patients experiencing failure of their first PI-based antiretroviral regimens. In logistic regression analysis, the probability of accumulating a new 90M mutation at virological failure was associated with the presence at baseline of minor mutation 36I (naturally occurring in approximately 25% of HIV clade B and in >80% of HIV non-clade-B viruses) (adjusted odds ratio, 13.5 [95% confidence interval, 1.89-95.6]; P=.009) and, possibly, of 10I/V. This suggests a potential role for the presence of 36I at baseline in predicting the appearance of 90M at virological failure.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:BalottaClaudiaC,
pubmed-author:BerrierJJ,
pubmed-author:CadeoGiampieroG,
pubmed-author:ChirianniAntonioA,
pubmed-author:Cozzi-LepriAlessandroA,
pubmed-author:De StefanoCarloC,
pubmed-author:ForbiciFedericaF,
pubmed-author:Italian Cohort Naive Antiretrovirals Study Group,
pubmed-author:OraniAnnaA,
pubmed-author:PernoCarlo FedericoCF,
pubmed-author:Stella MuraMariaM,
pubmed-author:ViolinMichelaM,
pubmed-author:d'Arminio MonforteAntonellaA
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
189
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1983-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15143463-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:15143463-Cohort Studies,
pubmed-meshheading:15143463-Drug Resistance, Viral,
pubmed-meshheading:15143463-Female,
pubmed-meshheading:15143463-HIV,
pubmed-meshheading:15143463-HIV Infections,
pubmed-meshheading:15143463-HIV Protease,
pubmed-meshheading:15143463-HIV Protease Inhibitors,
pubmed-meshheading:15143463-Humans,
pubmed-meshheading:15143463-Logistic Models,
pubmed-meshheading:15143463-Male,
pubmed-meshheading:15143463-Multivariate Analysis,
pubmed-meshheading:15143463-Point Mutation,
pubmed-meshheading:15143463-RNA, Viral,
pubmed-meshheading:15143463-Reverse Transcriptase Inhibitors,
pubmed-meshheading:15143463-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15143463-Sequence Analysis, DNA
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pubmed:year |
2004
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pubmed:articleTitle |
Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor antiretroviral regimens failed.
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pubmed:affiliation |
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, University of Rome Tor Vergata, Italy. cf.perno@uniroma2.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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