Linked Life Data

15137061

Source:http://linkedlifedata.com/resource/pubmed/id/15137061

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15137061rdf:typepubmed:Citationlld:pubmed
pubmed-article:15137061lifeskim:mentionsumls-concept:C0109317lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1705767lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0567416lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0017337lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0752312lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0449258lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1370600lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0752313lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1366882lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1150579lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1333340lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1705791lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1422561lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1511331lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1704259lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1705987lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0679622lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1314939lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C0205314lld:lifeskim
pubmed-article:15137061lifeskim:mentionsumls-concept:C1998811lld:lifeskim
pubmed-article:15137061pubmed:issue1lld:pubmed
pubmed-article:15137061pubmed:dateCreated2004-5-11lld:pubmed
pubmed-article:15137061pubmed:abstractTextBromodomain is a 110 amino acid domain. It is evolutionally conserved and is found in proteins strongly implicated in signal-dependent transcriptional regulation. BRD7 is a novel bromodomain gene and it is downexpressed in nasopharyngeal carcinoma (NPC) biopsies and cell lines; its function is poorly understood. In the present study, tet-on inducible expression system was used to investigate the role of BRD7 in cell growth and cell cycle progression. We found that ectopic expression of BRD7 in NPC cells inhibited cell growth and cell cycle progression from G1 to S. We further performed cell cycle cDNA array to screen potential transcriptional targets of BRD7 in cell cycle. Thirteen important signaling molecules, mainly implicated in ras/MEK/ERK and Rb/E2F pathways, were differentially expressed by induction of BRD7. Moreover, we observed that BRD7 could regulate the promoter activity of E2F3, one of its targets. Taken together, the present study indicated that BRD7 inhibited G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways and suggested that BRD7 may present a promising candidate of NPC trade mark associated tumor suppressor gene.lld:pubmed
pubmed-article:15137061pubmed:languageenglld:pubmed
pubmed-article:15137061pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:citationSubsetIMlld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15137061pubmed:statusMEDLINElld:pubmed
pubmed-article:15137061pubmed:monthJullld:pubmed
pubmed-article:15137061pubmed:issn0021-9541lld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:ZhouJieJlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:ZhouMingMlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:HuangHeHlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:LiXiao-LingXLlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:ShenShou-Rong...lld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:MaJianJlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:XiongWeiWlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:LiGui-YuanGYlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:ZhangBi-Cheng...lld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:ZhuShi-GuoSGlld:pubmed
pubmed-article:15137061pubmed:authorpubmed-author:LiuHua-YingHYlld:pubmed
pubmed-article:15137061pubmed:copyrightInfoCopyright 2004 Wiley-Liss, Inc.lld:pubmed
pubmed-article:15137061pubmed:issnTypePrintlld:pubmed
pubmed-article:15137061pubmed:volume200lld:pubmed
pubmed-article:15137061pubmed:ownerNLMlld:pubmed
pubmed-article:15137061pubmed:authorsCompleteYlld:pubmed
pubmed-article:15137061pubmed:pagination89-98lld:pubmed
pubmed-article:15137061pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:meshHeadingpubmed-meshheading:15137061...lld:pubmed
pubmed-article:15137061pubmed:year2004lld:pubmed
pubmed-article:15137061pubmed:articleTitleBRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways.lld:pubmed
pubmed-article:15137061pubmed:affiliationCancer Research Institute, Xiang-Ya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China.lld:pubmed
pubmed-article:15137061pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15137061pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:29117entrezgene:pubmedpubmed-article:15137061lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15137061lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15137061lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15137061lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15137061lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15137061lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15137061lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15137061lld:pubmed
More...