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pubmed-article:15136641pubmed:abstractTextRoutine application of (18)F-labeled peptides for quantitative in vivo receptor imaging of receptor-expressing tissues and quantification of receptor status using PET is limited by the lack of appropriate radiofluorination methods for routine large-scale synthesis of (18)F-labeled peptides. To satisfy this demand, a new (18)F-labeling methodology based on the chemoselective oxime formation between an unprotected aminooxy-functionalized peptide and an (18)F-labeled aldehyde or ketone was investigated and optimized with respect to peptide conjugation.lld:pubmed
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pubmed-article:15136641pubmed:articleTitleTwo-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.lld:pubmed
pubmed-article:15136641pubmed:affiliationNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.lld:pubmed
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