rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2004-5-11
|
pubmed:abstractText |
Routine application of (18)F-labeled peptides for quantitative in vivo receptor imaging of receptor-expressing tissues and quantification of receptor status using PET is limited by the lack of appropriate radiofluorination methods for routine large-scale synthesis of (18)F-labeled peptides. To satisfy this demand, a new (18)F-labeling methodology based on the chemoselective oxime formation between an unprotected aminooxy-functionalized peptide and an (18)F-labeled aldehyde or ketone was investigated and optimized with respect to peptide conjugation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0161-5505
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
45
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
892-902
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15136641-Animals,
pubmed-meshheading:15136641-Fluorine Radioisotopes,
pubmed-meshheading:15136641-Halogens,
pubmed-meshheading:15136641-Humans,
pubmed-meshheading:15136641-Isotope Labeling,
pubmed-meshheading:15136641-Mice,
pubmed-meshheading:15136641-Mice, Nude,
pubmed-meshheading:15136641-Neoplasms, Experimental,
pubmed-meshheading:15136641-Oximes,
pubmed-meshheading:15136641-Peptides,
pubmed-meshheading:15136641-Radiopharmaceuticals,
pubmed-meshheading:15136641-Rats,
pubmed-meshheading:15136641-Tissue Distribution,
pubmed-meshheading:15136641-Tomography, Emission-Computed
|
pubmed:year |
2004
|
pubmed:articleTitle |
Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.
|
pubmed:affiliation |
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|