Source:http://linkedlifedata.com/resource/pubmed/id/15133483
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-6-21
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| pubmed:abstractText |
An increased incidence of late cytomegalovirus (CMV) infection has been reported during the last decade since the introduction of ganciclovir (GCV) prophylaxis or GCV pre-emptive therapy. Given that a donor lymphocyte infusion (DLI) can induce more severe GVHD, this may predispose a patient to late CMV infection. In all, 64 patients (median age 36, M/F 38/26) underwent allogeneic stem cell transplantation (SCT) using a matched sibling donor with bone marrow (n=9) or peripheral blood stem cells (n=55). The overall incidence of CMV infection, early and late CMV infection was 46.9 (30/64), 42.2 (27/64), and 16.4% (9/55), respectively. Early CMV infection was treated with GCV pre-emptive therapy that produced a 92.6% success rate. Among the 20 patients who received 35 DLIs, late CMV infection developed in eight (42.1%) of 19 evaluable cases with a median onset at 127 days post transplant. Risk factors for late CMV infection in a logistic regression analysis included DLIs (P=0.001) and a previous history of CMV infection (P=0.006). In conclusion, late CMV infection was strongly associated with DLIs and a previous history of early CMV infection. Accordingly, extended surveillance of CMV antigenemia is recommended for patients receiving DLIs or who have a previous history of CMV infection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
34
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
21-7
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| pubmed:meshHeading |
pubmed-meshheading:15133483-Adult,
pubmed-meshheading:15133483-Cytomegalovirus Infections,
pubmed-meshheading:15133483-Female,
pubmed-meshheading:15133483-Follow-Up Studies,
pubmed-meshheading:15133483-Ganciclovir,
pubmed-meshheading:15133483-Graft vs Host Disease,
pubmed-meshheading:15133483-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15133483-Histocompatibility Testing,
pubmed-meshheading:15133483-Humans,
pubmed-meshheading:15133483-Incidence,
pubmed-meshheading:15133483-Lymphocyte Transfusion,
pubmed-meshheading:15133483-Male,
pubmed-meshheading:15133483-Recurrence,
pubmed-meshheading:15133483-Retrospective Studies,
pubmed-meshheading:15133483-Risk Factors,
pubmed-meshheading:15133483-Siblings,
pubmed-meshheading:15133483-Time,
pubmed-meshheading:15133483-Transplantation, Homologous
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Risk factors for late cytomegalovirus infection after allogeneic stem cell transplantation using HLA-matched sibling donor: donor lymphocyte infusion and previous history of early CMV infection.
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| pubmed:affiliation |
Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu 700-721, Korea.
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| pubmed:publicationType |
Journal Article
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