Linked Life Data

15130595

Source:http://linkedlifedata.com/resource/pubmed/id/15130595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-5-7
pubmed:abstractText
Aim of the study was to investigate the degree of similarity of twin brains with respect to their outer shape and gyrification. High resolution MRI was obtained from 26 healthy monozygotic twins (MZ) and three-dimensional renderings of the brains were generated. Similarity was rated by human investigators and by computer analysis. Three different image types were analyzed: whole-brain views, silhouettes and a bird's-eye view of a segment showing the central region. For each of the three image types, 13 tasks (identifying the related twin-pair out of a set of five brains) had to be solved by the human raters. For whole brain, views and silhouettes 66/91(p<0.005) and for segment views 44/91 (p<0.02) correct identifications were made. Using cross correlation coefficients, the computer-based analysis as well significantly often identified related twins. Again correct identification was more likely based on whole-brain views and silhouettes than on segment views of the central region. In conclusion, we found that overall brain shape is probably strongly influenced by genetic effects but the variation in sulcal and gyral patterns is also affected by non-genetic influences to a considerable extent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0926-6410
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Elsevier B.V.
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-10
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The similarity of brain morphology in healthy monozygotic twins.
pubmed:affiliation
Department of Neuroradiology, University of Göttingen/Heidelberg, Robert-Koch Str. 40, 37075 Göttingen, Germany. alexander.mohr@med.uni-goettingen.de
pubmed:publicationType
Journal Article, Twin Study