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pubmed-article:15129882pubmed:abstractTextQuality of life instruments are frequently used as outcomes in randomized trials. Instruments that consist of several subscales present researchers with a choice of whether to combine some or all scales into a single composite score. There may be several clinically and scientifically reasonable alternative combinations of subscales for the primary outcome measure.lld:pubmed
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pubmed-article:15129882pubmed:articleTitleStatistical considerations for use of composite health-related quality-of-life scores in randomized trials.lld:pubmed
pubmed-article:15129882pubmed:affiliationIntegrative Medicine Service, Biostatistics Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. vickersa@mskcc.orglld:pubmed
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