Linked Life Data

15116402

Source:http://linkedlifedata.com/resource/pubmed/id/15116402

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-4-29
pubmed:abstractText
The feasibility of the use of a copolymer gel prepared from blends of polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) for endoscopic replacement of the nucleus pulposus of a lumbar intervertebral disc was examined in this study. Hydrogels were processed with the use of three freeze/thaw cycles to induce crystallinity. As-prepared samples were dehydrated to various levels: 70.4, 46.3, 25.1, and 10.3% of their as-prepared masses and subsequently rehydrated. The dehydration history controlled the dimensions upon swelling and caused distortion of the material, with major distortion occurring when the hydrogel reached around 25% of the initial hydrated mass. The dehydration history affected the mechanical behavior of the rehydrated gels. Increased dehydration resulted in increased compressive modulus for the reswollen gels. Experiments were performed to investigate the formation of a skin layer that was found on the hydrogels during the dehydration process. The skin was found to dehydrate quickly and form a barrier to further dehydration from the core. Rubber elasticity theory was used to describe the differences in the network characteristics between the skin and the core of a drying hydrogel. The dehydration/rehydration process used in this study and an implantation of a cadaver model demonstrate the feasibility of endoscopic nucleus replacement.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1552-4973
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-40
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The effect of dehydration history on PVA/PVP hydrogels for nucleus pulposus replacement.
pubmed:affiliation
Department of Materials Engineering, Drexel University, 32nd and Chestnut Streets, Philadelphia, Pennsylvania 19104, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Evaluation Studies