Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1992-9-25
|
| pubmed:abstractText |
In a 3-year prospective study, the prevalence of albuminuria and its relationship to macrovascular disease, pre-existing vascular risk factors and mortality rate were studied in a random cohort of 290 patients with Type 2 diabetes mellitus in general practice. Newly occurring micro- or macroalbuminuria was associated with significantly (p less than 0.05) higher systolic blood pressure: median (IQ range) 157 (140-170) vs 150 (130-160) mmHg, in addition to higher serum triglycerides: median (IQ range) 2.71 (1.84-4.25) vs 1.84 (1.35-3.14) mmol l-1, and C-peptide levels: median (IQ range) 1.30 (0.98-2.16) vs 1.10 (0.82-1.58) nmol l-1, at 3-year follow-up. Patients with macroalbuminuria at final examination had significantly higher systolic and diastolic blood pressure, serum triglyceride and beta 2-microglobulin levels, decreased HDL-cholesterol, and a significantly higher prevalence of carotid artery stenoses and peripheral vascular disease. Patients dying from vascular causes showed significantly higher urinary albumin levels at entrance as compared to the surviving patients: median (IQ range): 42.2 (11-249.7) vs 10.4 (4.6-28.0) mg l-1, p less than 0.008, and overall mortality rate was significantly linked with the presence of macroalbuminuria (26% vs 5% in normoalbuminuric patients). A comparison between the results of the initial and the final examination indicated an overall worsening of renal variables (albuminuria: median (IQ range): female 9.5 (4.5-21) vs 13.4 (5.1-39.7) mg l-1, (p less than 0.05); male 13.8 (4.7-34.1) vs 32.6 (8.1-78.7) (p less than 0.001), despite a significant improvement in metabolic variables.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0742-3071
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
646-53
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1511572-Age Factors,
pubmed-meshheading:1511572-Aged,
pubmed-meshheading:1511572-Albuminuria,
pubmed-meshheading:1511572-Blood Pressure,
pubmed-meshheading:1511572-Cohort Studies,
pubmed-meshheading:1511572-Coronary Disease,
pubmed-meshheading:1511572-Diabetes Mellitus, Type 2,
pubmed-meshheading:1511572-Family Practice,
pubmed-meshheading:1511572-Female,
pubmed-meshheading:1511572-Germany,
pubmed-meshheading:1511572-Humans,
pubmed-meshheading:1511572-Male,
pubmed-meshheading:1511572-Middle Aged,
pubmed-meshheading:1511572-Morbidity,
pubmed-meshheading:1511572-Prospective Studies,
pubmed-meshheading:1511572-Random Allocation,
pubmed-meshheading:1511572-Risk Factors,
pubmed-meshheading:1511572-Sex Characteristics
|
| pubmed:articleTitle |
Morbidity, mortality, and albuminuria in type 2 diabetic patients: a three-year prospective study of a random cohort in general practice.
|
| pubmed:affiliation |
Third Medical Department, City Hospital Schwabing, Munich, Germany.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|