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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2004-4-19
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pubmed:abstractText |
Endothelial dysfunction is an early, pre-clinical manifestation of coronary heart disease and is associated with increased plasma levels of von Willebrand factor (vWF), soluble E-selectin, and thrombomodulin, markers of endothelial cell damage/activation and reduced nitric oxide bioavailability. Homocysteine is associated with an increased risk of cardiovascular disease and mortality. High-dose folic acid treatment lowers plasma homocysteine by 25% and improves nitric oxide bioavailability; however, the effects on other indices of endothelial cell activation/damage has not been examined in patients with coronary heart disease and normal renal function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0167-5273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15093982-Aged,
pubmed-meshheading:15093982-Biological Markers,
pubmed-meshheading:15093982-Coronary Disease,
pubmed-meshheading:15093982-Cross-Over Studies,
pubmed-meshheading:15093982-Double-Blind Method,
pubmed-meshheading:15093982-E-Selectin,
pubmed-meshheading:15093982-Endothelium, Vascular,
pubmed-meshheading:15093982-Female,
pubmed-meshheading:15093982-Folic Acid,
pubmed-meshheading:15093982-Hematinics,
pubmed-meshheading:15093982-Humans,
pubmed-meshheading:15093982-Male,
pubmed-meshheading:15093982-Middle Aged,
pubmed-meshheading:15093982-Nitric Oxide,
pubmed-meshheading:15093982-Thrombomodulin,
pubmed-meshheading:15093982-Time Factors,
pubmed-meshheading:15093982-Vasodilation,
pubmed-meshheading:15093982-von Willebrand Factor
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pubmed:year |
2004
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pubmed:articleTitle |
Short-term high-dose folic acid does not alter markers of endothelial cell damage in patients with coronary heart disease.
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pubmed:affiliation |
Cardiovascular Sciences Research Group, Department of Pharmacology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK. Sagar.Doshi@msnyuhealth.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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