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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5073
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pubmed:dateCreated |
1992-9-23
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pubmed:abstractText |
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1134-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1509265-Animals,
pubmed-meshheading:1509265-Antigen-Presenting Cells,
pubmed-meshheading:1509265-Antigens,
pubmed-meshheading:1509265-Base Sequence,
pubmed-meshheading:1509265-Binding Sites,
pubmed-meshheading:1509265-Blotting, Northern,
pubmed-meshheading:1509265-Cell Line,
pubmed-meshheading:1509265-Concanavalin A,
pubmed-meshheading:1509265-Gene Expression Regulation,
pubmed-meshheading:1509265-Immune Tolerance,
pubmed-meshheading:1509265-Interleukin-2,
pubmed-meshheading:1509265-Mice,
pubmed-meshheading:1509265-Molecular Sequence Data,
pubmed-meshheading:1509265-Mutation,
pubmed-meshheading:1509265-Promoter Regions, Genetic,
pubmed-meshheading:1509265-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:1509265-RNA, Messenger,
pubmed-meshheading:1509265-Receptors, Antigen, T-Cell,
pubmed-meshheading:1509265-T-Lymphocytes,
pubmed-meshheading:1509265-Transcription, Genetic,
pubmed-meshheading:1509265-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Transactivation by AP-1 is a molecular target of T cell clonal anergy.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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