Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-4-16
pubmed:abstractText
Advances in medical technology have increased the number of individuals who survive cardiac arrest/cardiopulmonary resuscitation (CPR). This increased incidence of survival has created a population of patients with behavioral and physiologic impairments. We used temperature manipulations to characterize the contribution of central nervous system damage to behavioral deficits elicited by 8 minutes of cardiac arrest/CPR in a mouse model. Once sensorimotor deficits were resolved, we examined anxiety-like behavior with the elevated plus maze and social interaction with an ovariectomized female. We hypothesized that anxiety-like behavior would increase and social interaction would decrease in mice subjected to cardiac arrest/CPR and that these changes would be attributable to central nervous system damage rather than damage to peripheral organs or changes orchestrated by the administration of epinephrine. Mice that were subjected to cardiac arrest/CPR while the peripheral organs, but not the brain, were protected by hypothermia exhibited increased anxiety-like behavior and decreased social interaction, whereas mice with hypothermic brains and peripheral organs during cardiac arrest/CPR did not exhibit behavioral impairments. The present study demonstrates that central nervous system damage from cardiac arrest/CPR results in increased anxiety and decreased social interaction and that these behavioral changes are not attributed to underlying sensorimotor deficits, dynamics of arrest and CPR, or peripheral organ damage.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10064884, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10360132, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10435198, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10500268, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10593621, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10706216, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10837844, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-10926961, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11004378, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11082483, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11114453, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11302295, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11334694, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11566205, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11726787, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11734233, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11845545, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11856793, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11872264, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-11897619, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12012430, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12108816, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12398769, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12576962, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12742737, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12826637, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-12930357, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-1993914, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-2586113, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-2864480, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-6614228, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-7774331, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-8446790, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-8599172, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-8733020, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-9079772, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-9316194, http://linkedlifedata.com/resource/pubmed/commentcorrection/15087706-9989536
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0271-678X
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
372-82
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction.
pubmed:affiliation
Department of Psychology, The Ohio State University, Columbus 43210, USA. neigh.1@osu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't