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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-4-14
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pubmed:abstractText |
The aim of this study is to evaluate the rate of axillary recurrences in sentinel lymph node (SLN)-negative breast cancer patients after sentinel lymph node biopsy (SLNB) alone without further axillary lymph node dissection (ALND). Between May 1999 and February 2002, 333 consecutive patients with primary invasive breast cancer up to 4 cm and clinically negative axillae were entered into this prospective study. Sentinel lymph nodes were identified using the combined method with blue dye (Patent blue V) and technetium 99m-labelled albumin (Nanocoll). Sentinel lymph nodes were examined by frozen sections, standard haematoxylin and eosin staining and immunohistochemistry staining. In SLN-positive patients, ALND was performed. Sentinel lymph node-negative patients had no further ALND. The SLN identification rate was 98.5% (328 out of 333). In all, 128 out of 328 (39.0%) patients had positive SLNs and complete ALND. A total of 200 out of 328 (61.0%) patients were SLN negative and had no further ALND. The mean tumour size of SLN-negative patients was 16.5 mm. The mean number of SLNs removed was 2.1 per patient. There were no local or axillary recurrences at a median follow-up of 36 months. The absence of axillary recurrences after SLNB without ALND in SLN-negative breast cancer patients supports the hypothesis that SLNB is accurate and safe while providing less surgical morbidity than ALND. Short-term results are very promising that SLNB without ALND in SLN-negative patients is an excellent procedure for axillary staging in a cohort of breast cancer patients with small tumours.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-11113430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-11200778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-11376416,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-11736979,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-12383890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-12711287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-12915872,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-3978244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-3995243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-6992972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-7705102,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15083184-9753708
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1551-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15083184-Axilla,
pubmed-meshheading:15083184-Breast Neoplasms,
pubmed-meshheading:15083184-Carcinoma,
pubmed-meshheading:15083184-Cohort Studies,
pubmed-meshheading:15083184-Female,
pubmed-meshheading:15083184-Follow-Up Studies,
pubmed-meshheading:15083184-Humans,
pubmed-meshheading:15083184-Lymph Node Excision,
pubmed-meshheading:15083184-Neoplasm Recurrence, Local,
pubmed-meshheading:15083184-Predictive Value of Tests,
pubmed-meshheading:15083184-Prognosis,
pubmed-meshheading:15083184-Sensitivity and Specificity,
pubmed-meshheading:15083184-Sentinel Lymph Node Biopsy
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pubmed:year |
2004
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pubmed:articleTitle |
200 Sentinel lymph node biopsies without axillary lymph node dissection -- no axillary recurrences after a 3-year follow-up.
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pubmed:affiliation |
Department of Senology, University Hospital Salzburg, Paracelsus Private Medical School Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria. r.reitsamer@lks.at
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pubmed:publicationType |
Journal Article
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