Source:http://linkedlifedata.com/resource/pubmed/id/15080303
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2004-4-14
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| pubmed:abstractText |
We describe 15 patients (9 children) with precursor B-cell (pB) acute lymphoblastic leukemia (ALL) with surface immunoglobulin (sIg) light chain restriction revealed by flow cytometric immunophenotyping (FCI). The same sIg+ immunophenotype was present at diagnosis and in 3 relapses in 1 patient. In 15 patients, blasts were CD19+ CD10+ (bright coexpression) in 14, CD34+ in 12, surface kappa+ in 12, surface lambda+ in 3; in 8 of 8, terminal deoxyribonucleotidyl transferase (TdT)+; and in 4, surface IgD+ in 2 and surface IgM+ in 1. The 3 CD34- cases included 1 TdT+ case, 1 with t(1;19)(q23;p13), and 1 infant with 70% marrow blasts. One adult had CD10- CD19+ CD20- CD22+ CD34+ TdT+ sIg+ blasts with t(2;11)(p21;q23). Blasts were L1 or L2 in all cases (French-American-British classification). Karyotypic analysis in 12 of 12 analyzable cases was negative for 8q24 (myc) translocation. Karyotypic abnormalities, confirmed by fluorescence in situ hybridization in 6 cases, included hyperdiploidy, t(1;19)(q23;p13), t(12;21)(p13;q22), t(9;22)(q34;q11), t(2;11)(p21;q23), and trisomy 12. The sIg light chain restriction in pB ALL might be present in neoplasms arising from the early, intermediate, and late stages of precursor B-cell maturation; sIg light chain restriction revealed by FCI does not necessarily indicate a mature B-cell phenotype, further emphasizing the importance of a multidisciplinary approach to diagnosing B-lymphoid neoplasms.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0002-9173
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
121
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
512-25
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15080303-Adolescent,
pubmed-meshheading:15080303-Adult,
pubmed-meshheading:15080303-Aged,
pubmed-meshheading:15080303-Antigens, CD,
pubmed-meshheading:15080303-B-Lymphocytes,
pubmed-meshheading:15080303-Child,
pubmed-meshheading:15080303-Child, Preschool,
pubmed-meshheading:15080303-Chromosome Aberrations,
pubmed-meshheading:15080303-Female,
pubmed-meshheading:15080303-Flow Cytometry,
pubmed-meshheading:15080303-Humans,
pubmed-meshheading:15080303-Immunoglobulin Light Chains,
pubmed-meshheading:15080303-Immunophenotyping,
pubmed-meshheading:15080303-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15080303-Male,
pubmed-meshheading:15080303-Middle Aged,
pubmed-meshheading:15080303-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15080303-Stem Cells
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Precursor B lymphoblastic leukemia with surface light chain immunoglobulin restriction: a report of 15 patients.
|
| pubmed:affiliation |
Department of Pathology, Buffalo General Hospital, the State University of New York at Buffalo, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|