Linked Life Data

15078482

Source:http://linkedlifedata.com/resource/pubmed/id/15078482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-4-13
pubmed:abstractText
Nuclear factor kappa B (NF-kappaB) activation, proinflammatory cytokines, and reactive oxygen species have been implicated as mediators of liver injury and fibrogenesis. We have shown recently that pyrrolidine dithiocarbamate (PDTC), an antioxidant and inhibitor of NF-kappaB activation, was protective in a rat model of acute liver failure. The aim of the present study was to examine the efficacy of PDTC in a chronic rat model of thioacetamide (TAA)-induced hepatic fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1478-3223
pubmed:author
pubmed:copyrightInfo
Copyright Blackwell Munksgaard 2004
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-76
pubmed:meshHeading
pubmed-meshheading:15078482-Animals, pubmed-meshheading:15078482-Antioxidants, pubmed-meshheading:15078482-Cell Line, Transformed, pubmed-meshheading:15078482-Disease Models, Animal, pubmed-meshheading:15078482-Dose-Response Relationship, Drug, pubmed-meshheading:15078482-Hydroxyproline, pubmed-meshheading:15078482-Immunohistochemistry, pubmed-meshheading:15078482-In Situ Hybridization, pubmed-meshheading:15078482-Injections, Intraperitoneal, pubmed-meshheading:15078482-Liver, pubmed-meshheading:15078482-Liver Cirrhosis, Experimental, pubmed-meshheading:15078482-Male, pubmed-meshheading:15078482-NF-kappa B, pubmed-meshheading:15078482-Oxidative Stress, pubmed-meshheading:15078482-Pyrrolidines, pubmed-meshheading:15078482-Rats, pubmed-meshheading:15078482-Rats, Wistar, pubmed-meshheading:15078482-Thioacetamide, pubmed-meshheading:15078482-Thiobarbituric Acid Reactive Substances, pubmed-meshheading:15078482-Thiocarbamates
pubmed:year
2004
pubmed:articleTitle
A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis.
pubmed:affiliation
Department of Gastroenterology, The E. Wolfson Medical Center, Holon, Israel. rbruck@wolfson.health.gov.il
pubmed:publicationType
Journal Article