Linked Life Data

15073451

Source:http://linkedlifedata.com/resource/pubmed/id/15073451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-4-16
pubmed:abstractText
Preclinical and limited clinical data suggest that statins decrease the progressive decline in renal function that occurs in patients with renal disease. Pooled analysis of data obtained from a population of hyperlipidemic patients enrolled in the rosuvastatin (Crestor) clinical development program permitted assessment of its effects on renal function both early and later in the course of treatment. Study participants were initially included in controlled clinical trials that evaluated the lipid-lowering efficacy and safety of rosuvastatin when compared with placebo or other lipid-lowering agents (i.e., atorvastatin, simvastatin, pravastatin, cholestyramine, fenofibrate or extended-release niacin). The median duration of treatment with the various doses of statins in these trials was approximately 8 weeks. Following completion of a controlled clinical trial, patients were permitted to enter an open-label extension trial and received rosuvastatin treatment. These data permitted assessment of renal function in a diverse group of over 10,000 patients who received rosuvastatin in its recommended dose range (5-40 mg) for up to 3.8 years. Mean serum creatinine concentrations were lower when compared with baseline both early and later in the course of rosuvastatin treatment. In contrast, no change in mean serum creatinine was observed with placebo. Mean glomerular filtration rates (GFR) predicted from the Modification of Diet in Renal Disease (MDRD) equation were higher when compared with baseline both early and later in the course of rosuvastatin treatment. No change in GFR was observed in the placebo group. Among patients who received long-term rosuvastatin treatment (> or =96 weeks), GFR was unchanged or tended to increase, rather than decrease, when compared with baseline irrespective of age, gender, hypertensive or diabetic status, level of renal function (GFR > or =60 vs. <60 ml/min/1.73 m(2)) at entry or urine dipstick protein status prior to or during the period of treatment. These findings suggest that rosuvastatin may arrest the progression of renal disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0008-6312
pubmed:author
pubmed:copyrightInfo
Copyright 2004 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-60
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15073451-Aged, pubmed-meshheading:15073451-Controlled Clinical Trials as Topic, pubmed-meshheading:15073451-Creatine, pubmed-meshheading:15073451-Disease Progression, pubmed-meshheading:15073451-Drug Administration Schedule, pubmed-meshheading:15073451-Female, pubmed-meshheading:15073451-Fluorobenzenes, pubmed-meshheading:15073451-Glomerular Filtration Rate, pubmed-meshheading:15073451-Heptanoic Acids, pubmed-meshheading:15073451-Humans, pubmed-meshheading:15073451-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:15073451-Hypolipidemic Agents, pubmed-meshheading:15073451-Kidney, pubmed-meshheading:15073451-Kidney Diseases, pubmed-meshheading:15073451-Male, pubmed-meshheading:15073451-Middle Aged, pubmed-meshheading:15073451-Pravastatin, pubmed-meshheading:15073451-Pyrimidines, pubmed-meshheading:15073451-Pyrroles, pubmed-meshheading:15073451-Simvastatin, pubmed-meshheading:15073451-Sulfonamides
pubmed:year
2004
pubmed:articleTitle
Rosuvastatin-induced arrest in progression of renal disease.
pubmed:affiliation
Cleveland Clinic Foundation, Cleveland, Ohio, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Meta-Analysis