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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-9-24
|
| pubmed:abstractText |
Urinary excretion of 3-methylhistidine has been proposed as an index of internal protein breakdown provided that the intake of exogenous 3-methylhistidine (meat) is excluded. To evaluate the potential use of 3-methylhistidine in the metabolic assessment of patients with advanced renal failure, we studied a group of 11 patients with markedly reduced renal function who were put on a meat-free diet (the protein intake was kept constant). Steady-state plasma concentration and urinary excretion of 3-methylhistidine were not achieved until 14 d after exclusion of meat from the diet. At that time the plasma concentration and urinary excretion of 3-methylhistidine had decreased by 43% and 60%, respectively. We conclude that the delay in reaching steady state makes the clinical use of urinary excretion of 3-methylhistidine in patients with advanced renal failure unpracticable as an index of protein breakdown. The exclusion of meat also resulted in a continuous decrease in the plasma level and urinary excretion of creatinine, with the result that plasma creatinine or its reciprocal become misleading for evaluation of changes in renal function until a new steady state has been reached.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0954-6820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
232
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
129-32
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1506808-Adult,
pubmed-meshheading:1506808-Aged,
pubmed-meshheading:1506808-Creatinine,
pubmed-meshheading:1506808-Female,
pubmed-meshheading:1506808-Humans,
pubmed-meshheading:1506808-Kidney Failure, Chronic,
pubmed-meshheading:1506808-Male,
pubmed-meshheading:1506808-Meat,
pubmed-meshheading:1506808-Methylhistidines,
pubmed-meshheading:1506808-Middle Aged
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Influence of a meat-free diet on the urinary excretion of 3-methylhistidine and creatinine in chronic renal failure.
|
| pubmed:affiliation |
Department of Renal Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
|
| pubmed:publicationType |
Journal Article
|