Source:http://linkedlifedata.com/resource/pubmed/id/15064027
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9415
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| pubmed:dateCreated |
2004-4-5
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| pubmed:abstractText |
In response to the emergence of severe infection capable of rapid global spread, WHO will issue a pandemic alert. Such alerts are rare; however, on Feb 19, 2003, a pandemic alert was issued in response to human infections caused by an avian H5N1 influenza virus, A/Hong Kong/213/03. H5N1 had been noted once before in human beings in 1997 and killed a third (6/18) of infected people. The 2003 variant seemed to have been transmitted directly from birds to human beings and caused fatal pneumonia in one of two infected individuals. Candidate vaccines were sought, but no avirulent viruses antigenically similar to the pathogen were available, and the isolate killed embryonated chicken eggs. Since traditional strategies of vaccine production were not viable, we sought to produce a candidate reference virus using reverse genetics.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1474-547X
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
3
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| pubmed:volume |
363
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1099-103
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:15064027-Animals,
pubmed-meshheading:15064027-Antibodies, Viral,
pubmed-meshheading:15064027-Asia,
pubmed-meshheading:15064027-Birds,
pubmed-meshheading:15064027-Communicable Disease Control,
pubmed-meshheading:15064027-Disease Outbreaks,
pubmed-meshheading:15064027-Drug Design,
pubmed-meshheading:15064027-Genetic Engineering,
pubmed-meshheading:15064027-Hong Kong,
pubmed-meshheading:15064027-Humans,
pubmed-meshheading:15064027-Influenza A virus,
pubmed-meshheading:15064027-Influenza Vaccines,
pubmed-meshheading:15064027-Influenza in Birds,
pubmed-meshheading:15064027-Orthomyxoviridae,
pubmed-meshheading:15064027-Orthomyxoviridae Infections,
pubmed-meshheading:15064027-Plasmids,
pubmed-meshheading:15064027-Poultry Diseases,
pubmed-meshheading:15064027-Reassortant Viruses,
pubmed-meshheading:15064027-Transformation, Genetic,
pubmed-meshheading:15064027-Virulence Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines.
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| pubmed:affiliation |
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA. richard.webby@stjude.org
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|