Linked Life Data

15063086

Source:http://linkedlifedata.com/resource/pubmed/id/15063086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-4-5
pubmed:abstractText
Endothelin (ET) is a potent vasoconstrictive peptide that was isolated initially from the conditioned medium of cultured endothelial cells. In 1988, details of the isolation and identification, amino acid sequence, cDNA sequence and pharmacology of ET were published. Subsequently, ET isoforms, ET receptors and endothelin-converting enzyme (ECE) were cloned. Because ET was thought to be important in cardiovascular homeostasis, many investigators focused on the physiological and pathophysiological significance of ET. Accordingly, ET receptor antagonists and ECE inhibitors have been developed rapidly, mostly for the treatment of cardiovascular diseases. The field of molecular biology has provided valuable information about ET, including evidence that the ET system plays important roles in the early development of the neural crest and, thus, in the formation of organs. These results now present new avenues of ET research.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-6147
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-24
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Historical review: Endothelin.
pubmed:affiliation
Osaka Seikei University, 3-10-62 Aikawa Higashi-Yodogawa-ku, Osaka City, 533-0007, Japan. masakitt@osaka-seikei.ac.jp
pubmed:publicationType
Journal Article, Historical Article