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pubmed:abstractText |
Several Bcl-2 family members, including Bim, may contribute to programmed cell death by inducing mitochondrial cytochrome c release, which activates caspase-9 and then caspase-3, the "executioner" of the cell. In this issue of the JCI, Shinoda and collaborators show the key role of Bim in epileptic seizure-induced neuronal injury and identify the contribution of transcription factors responsible for seizure-induced Bim upregulation.
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pubmed:affiliation |
Epilepsy Research Laboratory, Veteran's Administration Greater Los Angeles Healthcare System, West Los Angeles, California 90073, USA. jniquet@ucla.edu
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