Linked Life Data

15043439

Source:http://linkedlifedata.com/resource/pubmed/id/15043439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-3-26
pubmed:abstractText
A new flavonoid (1) was isolated from organic extracts of Dalea versicolor, along with six known phenolic compounds (2-7). The structures of the seven compounds were determined by NMR and HRMS methods. These compounds were evaluated for direct activity against a variety of organisms in vitro, including the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus. In addition, the compounds were evaluated for their ability to potentiate the activity of known antimicrobials through inhibition of multidrug-resistance (MDR) pumps. Compounds 1, 2, 4, and 7 exhibited direct or synergistic activity toward the human pathogen S. aureus and the opportunistic pathogen B. cereus. Compounds 4 and 7 were also found to potentiate the activity of berberine and of prescribed antibiotics, with 4 demonstrating a mode of action consistent with inhibition of the NorA MDR efflux pump in S. aureus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0163-3864
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria.
pubmed:affiliation
Department of Chemistry and Biochemistry, The University of Tulsa, Tulsa, Oklahoma 74101, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't