Linked Life Data

15043041

Source:http://linkedlifedata.com/resource/pubmed/id/15043041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-3-25
pubmed:abstractText
Intense research has focused on methods for overcoming the various barriers to DNA delivery while simultaneously reducing toxicity. Recently, Yuan and colleagues discovered a 'leakage route', whereby viral vectors escaped the injection site and entered the systemic circulation and contributed to the systemic toxicity in cancer gene therapy. They also demonstrated that alginate solution sealed this leak. Although their work focused on intratumoral injection of viral vectors, the findings can be extended to drug delivery in general, particularly DNA delivery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0167-7799
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
A new solution for improving gene delivery.
pubmed:affiliation
Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14850, USA. dl79@cornell.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't