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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2004-3-30
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pubmed:abstractText |
Clinical trials have demonstrated that agents that inhibit the angiotensin II pathway confer benefit beyond the reduction of blood pressure alone. However, the molecular mechanism underlying this effect has yet to be investigated. Recently, we have demonstrated enhanced expression of inducible cyclooxygenase (COX) and prostaglandin (PG)E2-dependent synthase (COX-2/mPGES-1) in human symptomatic plaques and provided evidence that it is associated with metalloproteinase (MMP)-induced plaque rupture. Thus, the aim of this study was to characterize the effect of the angiotensin II type 1 (AT1) receptor antagonist irbesartan on the inflammatory infiltration and expression of COX-2/mPGES-1 and MMPs in human carotid plaques.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin I,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorthalidone,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/irbesartan,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin-E synthase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BeiRobertoR,
pubmed-author:BucciMarcoM,
pubmed-author:CipolloneFrancescoF,
pubmed-author:CuccurulloChiaraC,
pubmed-author:CuccurulloFrancoF,
pubmed-author:De LucaMariellaM,
pubmed-author:FaziaMariaM,
pubmed-author:IezziAnnalisaA,
pubmed-author:MezzettiAndreaA,
pubmed-author:MuraroRaffaellaR,
pubmed-author:PiniBarbaraB,
pubmed-author:SpigonardoFrancescoF,
pubmed-author:UcchinoSanteS,
pubmed-author:ZucchelliMircoM,
pubmed-author:de CesareDomenicoD
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1482-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15037537-Aged,
pubmed-meshheading:15037537-Angiotensin I,
pubmed-meshheading:15037537-Angiotensin II,
pubmed-meshheading:15037537-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:15037537-Antihypertensive Agents,
pubmed-meshheading:15037537-Biphenyl Compounds,
pubmed-meshheading:15037537-Carotid Artery, Internal,
pubmed-meshheading:15037537-Carotid Stenosis,
pubmed-meshheading:15037537-Chlorthalidone,
pubmed-meshheading:15037537-Collagen,
pubmed-meshheading:15037537-Combined Modality Therapy,
pubmed-meshheading:15037537-Cyclooxygenase 1,
pubmed-meshheading:15037537-Cyclooxygenase 2,
pubmed-meshheading:15037537-Depression, Chemical,
pubmed-meshheading:15037537-Dinoprostone,
pubmed-meshheading:15037537-Endarterectomy, Carotid,
pubmed-meshheading:15037537-Enzyme Induction,
pubmed-meshheading:15037537-Extracellular Matrix,
pubmed-meshheading:15037537-Female,
pubmed-meshheading:15037537-Gene Expression Regulation,
pubmed-meshheading:15037537-Humans,
pubmed-meshheading:15037537-Inflammation,
pubmed-meshheading:15037537-Intramolecular Oxidoreductases,
pubmed-meshheading:15037537-Isoenzymes,
pubmed-meshheading:15037537-Macrophages,
pubmed-meshheading:15037537-Male,
pubmed-meshheading:15037537-Matrix Metalloproteinases,
pubmed-meshheading:15037537-Membrane Proteins,
pubmed-meshheading:15037537-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:15037537-Protease Inhibitors,
pubmed-meshheading:15037537-Rupture, Spontaneous,
pubmed-meshheading:15037537-Tetrazoles
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pubmed:year |
2004
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pubmed:articleTitle |
Blockade of the angiotensin II type 1 receptor stabilizes atherosclerotic plaques in humans by inhibiting prostaglandin E2-dependent matrix metalloproteinase activity.
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pubmed:affiliation |
G. d'Annunzio University of Chieti and the G. d'Annunzio University Foundation, Chieti, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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