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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 2
|
| pubmed:dateCreated |
1992-9-17
|
| pubmed:abstractText |
The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81% of colorectal cancer in patients under 35, however, by 65 about 85% are phenocopies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0003-4800
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
99-103
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1503398-Adult,
pubmed-meshheading:1503398-Aged,
pubmed-meshheading:1503398-Colorectal Neoplasms,
pubmed-meshheading:1503398-Female,
pubmed-meshheading:1503398-Gene Frequency,
pubmed-meshheading:1503398-Genes, Dominant,
pubmed-meshheading:1503398-Humans,
pubmed-meshheading:1503398-Male,
pubmed-meshheading:1503398-Middle Aged,
pubmed-meshheading:1503398-Pedigree
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Dominant genes for colorectal cancer are not rare.
|
| pubmed:affiliation |
Department of Community Medicine, Southampton General Hospital.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|