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pubmed-article:15033795pubmed:abstractTextThis study sought to identify the RV protein that causes apoptosis. For this purpose, we first compared the ability of G and N proteins of a pathogenic and a nonpathogenic strain to trigger apoptosis of Jurkat rtTA by using an inducible Tet-on expression system. Then we analyzed apoptosis induced by a reverse genetic-engineered recombinant rabies virus in which the G gene from a nonpathogenic strain was replaced by its pathogenic strain counterpart. No other virus proteins than G of nonpathogenic RV strains induce apoptosis, and the G polypeptide of RV is a critical determinant for apoptosis in human cells.lld:pubmed
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pubmed-article:15033795pubmed:pagination577-81lld:pubmed
pubmed-article:15033795pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15033795pubmed:articleTitleGlycoprotein of nonpathogenic rabies viruses is a major inducer of apoptosis in human jurkat T cells.lld:pubmed
pubmed-article:15033795pubmed:affiliationUnité de NeuroImmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France.lld:pubmed
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pubmed-article:15033795pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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