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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-3-22
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pubmed:abstractText |
This study sought to identify the RV protein that causes apoptosis. For this purpose, we first compared the ability of G and N proteins of a pathogenic and a nonpathogenic strain to trigger apoptosis of Jurkat rtTA by using an inducible Tet-on expression system. Then we analyzed apoptosis induced by a reverse genetic-engineered recombinant rabies virus in which the G gene from a nonpathogenic strain was replaced by its pathogenic strain counterpart. No other virus proteins than G of nonpathogenic RV strains induce apoptosis, and the G polypeptide of RV is a critical determinant for apoptosis in human cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0077-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1010
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
577-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
2003
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pubmed:articleTitle |
Glycoprotein of nonpathogenic rabies viruses is a major inducer of apoptosis in human jurkat T cells.
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pubmed:affiliation |
Unité de NeuroImmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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