Linked Life Data

15033427

Source:http://linkedlifedata.com/resource/pubmed/id/15033427

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2004-3-22
pubmed:abstractText
How signaling molecules in inhibitory interneurons modulate and coordinate the integration of synaptic inputs remains largely unknown. We investigated the kinetics and modulation of glutamatergic and cholinergic synapses on CA1 fast-spiking interneurons in hippocampal slices by using whole-cell clamp recording. Spontaneous synaptic currents mediated by either AMPA-type glutamate or nicotinic acetylcholine receptors on the interneurons can be classified into fast, slow and fast-slow based on their duration and decay phase. Effects of calcineurin, calmodulin-dependent protein phosphatase, on these two groups of synapses were examined by infusing an autoinhibitory peptide of calcineurin (CaN-AIP) into the recording neurons. CaN-AIP enhanced the amplitude of glutamatergic fast-EPSCs, as well as both amplitude and frequency of cholinergic fast-EPSCs. No significant changes in slow-EPSCs were observed during the infusion of CaN-AIP. Our results indicate that signal transmission at synapses, which are mediated by either AMPA-type glutamate or nicotinic acetylcholine receptors, appears different in the kinetics. The selective influence of calcineurin on different synapses in fast-spiking interneurons may play an important role in coordinating thousands of synaptic inputs in order to set neuronal excitability at proper levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
1004
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-35
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Differential modulation of glutamatergic and cholinergic synapses by calcineurin in hippocampal CA1 fast-spiking interneurons.
pubmed:affiliation
Department of Molecular Biosciences, University of Kansas, 4023 Haworth Hall, 1200 Sunnyside, Lawrence KS 66045, USA. jinhwang@ku.edu
pubmed:publicationType
Journal Article, In Vitro