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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-3-18
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pubmed:abstractText |
The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body weight and/or food intake in several rodent models. We report here the identification of a novel nonpeptidic MC4R antagonist and its effects on tumor-induced weight loss in mice following peripheral administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:BalaniSureshS,
pubmed-author:CaracotiAndreiA,
pubmed-author:CheJennifer LJL,
pubmed-author:ClaiborneChristopher FCF,
pubmed-author:DaiMingshiM,
pubmed-author:DrabicStacey VSV,
pubmed-author:FarrerCheryl ACA,
pubmed-author:ForsythNancy ENE,
pubmed-author:HorlickRobert ARA,
pubmed-author:JosephIngrid B J KIB,
pubmed-author:LamppuDianaD,
pubmed-author:LiPingP,
pubmed-author:MaguireMartin PMP,
pubmed-author:PataneMichael AMA,
pubmed-author:RodriguezLuis ELE,
pubmed-author:VosTricia JTJ,
pubmed-author:YoweDavid LDL,
pubmed-author:ZengHangH
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1602-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:15027849-Administration, Cutaneous,
pubmed-meshheading:15027849-Animals,
pubmed-meshheading:15027849-Benzamidines,
pubmed-meshheading:15027849-Emaciation,
pubmed-meshheading:15027849-Imidazoles,
pubmed-meshheading:15027849-Mice,
pubmed-meshheading:15027849-Mice, Inbred BALB C,
pubmed-meshheading:15027849-Neoplasm Transplantation,
pubmed-meshheading:15027849-Neoplasms,
pubmed-meshheading:15027849-Radioligand Assay,
pubmed-meshheading:15027849-Receptor, Melanocortin, Type 4,
pubmed-meshheading:15027849-Structure-Activity Relationship,
pubmed-meshheading:15027849-Transplantation, Heterologous
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pubmed:year |
2004
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pubmed:articleTitle |
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.
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pubmed:affiliation |
Department of Medicinal Chemistry, Millennium Pharmaceuticals, Inc., 40 Landsdowne Street, Cambridge, Massachusetts 02139, USA. tricia.vos@mpi.com
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pubmed:publicationType |
Journal Article
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