Linked Life Data

15027668

Source:http://linkedlifedata.com/resource/pubmed/id/15027668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-3-18
pubmed:abstractText
Surfactant Protein B (SP-B) deficiency has been recently identified as an uncommon, autosomal recessive lung disorder in term infants. This inability to produce SP-B leads to progressive, lethal, hypoxemic respiratory failure in the first year of life. A frameshift mutation (121 ins 2) is the predominant but not exclusive cause. The clue to diagnosis is to have a high suspicion of SP-B deficiency in any term infant with severe respiratory distress without any apparent cause. SP-B deficiency can be diagnosed prenatally or postnatally. The only current treatment options available include lung transplantation or compassionate care. Current developments in gene therapy offer hope for future treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
N
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0893-2190
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-7
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Surfactant protein B deficiency in infants with respiratory failure.
pubmed:affiliation
Neonatal Intensive Care Unit, Pediatrix Medical Group, Valley Hospital Medical Center, Las Vegas, NV 89106, USA. maryann_wilder@pediatrix.com
pubmed:publicationType
Journal Article, Review