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pubmed-article:1501888pubmed:abstractTextWe have examined the interactions and DNA-binding activities of the c-Myc oncoprotein and its partner Max. In cell extracts virtually all c-Myc molecules are associated with Max in heterodimeric complexes. Moreover, DNA-binding studies with in vitro-translated protein and cell extracts show that both Max alone and c-Myc/Max bind the same DNA sequence. Conversely, c-Myc is unable to bind this sequence in the absence of Max. These findings suggest that c-Myc may function via obligate complex formation with Max.lld:pubmed
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pubmed-article:1501888pubmed:articleTitleMax and c-Myc/Max DNA-binding activities in cell extracts.lld:pubmed
pubmed-article:1501888pubmed:affiliationBiochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, London, UK.lld:pubmed
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