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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1992-9-15
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pubmed:abstractText |
We have examined the interactions and DNA-binding activities of the c-Myc oncoprotein and its partner Max. In cell extracts virtually all c-Myc molecules are associated with Max in heterodimeric complexes. Moreover, DNA-binding studies with in vitro-translated protein and cell extracts show that both Max alone and c-Myc/Max bind the same DNA sequence. Conversely, c-Myc is unable to bind this sequence in the absence of Max. These findings suggest that c-Myc may function via obligate complex formation with Max.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0950-9232
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1783-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1501888-Animals,
pubmed-meshheading:1501888-Base Sequence,
pubmed-meshheading:1501888-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:1501888-Basic-Leucine Zipper Transcription Factors,
pubmed-meshheading:1501888-DNA,
pubmed-meshheading:1501888-DNA-Binding Proteins,
pubmed-meshheading:1501888-HeLa Cells,
pubmed-meshheading:1501888-Humans,
pubmed-meshheading:1501888-Molecular Sequence Data,
pubmed-meshheading:1501888-Polymers,
pubmed-meshheading:1501888-Precipitin Tests,
pubmed-meshheading:1501888-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:1501888-Rabbits,
pubmed-meshheading:1501888-Transcription Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Max and c-Myc/Max DNA-binding activities in cell extracts.
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pubmed:affiliation |
Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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