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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-9-11
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pubmed:abstractText |
We developed an assay to detect antibodies spontaneously secreted in vitro by peripheral blood mononuclear cells (PBMC) against Brucella spp. High levels of anti-Brucella immunoglobulin G (IgG) and/or IgM and/or IgA antibodies were detected in the cell supernatant solution of PBMC cultures for 12 patients suffering from acute or focalized brucellosis and for 5 patients recently vaccinated against brucellosis. This spontaneous in vitro antibody production disappeared 5 to 20 months after onset of clinical signs and 20 to 27 days after vaccination. The transient character of this anti-Brucella antibody production by PBMC is consistent with a temporary in vivo stimulation of the immune system by Brucella antigens. Detection of this secretion could improve the diagnosis of evolutive brucellosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-14902693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-1647420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-1899628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-2175705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-2590555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-2891982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-2899262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-2931478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-312871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-3257430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-6048204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1500535-6489630
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2200-3
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1500535-Adult,
pubmed-meshheading:1500535-Antibodies, Bacterial,
pubmed-meshheading:1500535-Antibody Specificity,
pubmed-meshheading:1500535-Bacteriological Techniques,
pubmed-meshheading:1500535-Brucella,
pubmed-meshheading:1500535-Brucellosis,
pubmed-meshheading:1500535-Evaluation Studies as Topic,
pubmed-meshheading:1500535-Humans,
pubmed-meshheading:1500535-Leukocytes, Mononuclear,
pubmed-meshheading:1500535-Male,
pubmed-meshheading:1500535-Middle Aged
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pubmed:year |
1992
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pubmed:articleTitle |
In vitro antibody secretion by peripheral blood mononuclear cells as an expression of the immune response to Brucella spp. in humans.
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pubmed:affiliation |
Institut de Biologie, Institut National de la Santé et de la Recherche Médicale, Montpellier, France.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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