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rdf:type |
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lifeskim:mentions |
umls-concept:C0010132,
umls-concept:C0022661,
umls-concept:C0027882,
umls-concept:C0030532,
umls-concept:C0034693,
umls-concept:C0175219,
umls-concept:C0205099,
umls-concept:C0671870,
umls-concept:C1113688,
umls-concept:C1314939,
umls-concept:C1515877,
umls-concept:C1521801,
umls-concept:C1879547
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-8
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pubmed:abstractText |
We examined the effects of centrally administered orexin-A on corticotropin-releasing factor (CRF)-containing neurons in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (CeA) of rats, using dual immunostaining for CRF and Fos. Ninety minutes after intracerebroventricular administration of orexin-A, approximately 96% and 45% of CRF-containing neurons expressed Fos-like immunoreactivity (LI) in the PVN and the CeA, respectively. We also examined the effects of immobilized stress and cold exposure on orexin-A-containing neurons in the rat hypothalamus using dual immunostaining for orexin-A and Fos. After immobilized stress for 20 min and cold exposure at 4 degrees C for 30 min, approximately 24% and 15% of orexin-A-containing neurons expressed Fos-LI, respectively. These results suggest that orexins in the central nervous system may be involved in the activation of central CRF neurons induced by stress.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0167-0115
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-91
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15003835-Amygdala,
pubmed-meshheading:15003835-Animals,
pubmed-meshheading:15003835-Brain,
pubmed-meshheading:15003835-Catheterization,
pubmed-meshheading:15003835-Cell Count,
pubmed-meshheading:15003835-Central Nervous System,
pubmed-meshheading:15003835-Cold Temperature,
pubmed-meshheading:15003835-Corticotropin-Releasing Hormone,
pubmed-meshheading:15003835-Immunohistochemistry,
pubmed-meshheading:15003835-Injections, Intraventricular,
pubmed-meshheading:15003835-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15003835-Male,
pubmed-meshheading:15003835-Neurons,
pubmed-meshheading:15003835-Neuropeptides,
pubmed-meshheading:15003835-Paraventricular Hypothalamic Nucleus,
pubmed-meshheading:15003835-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:15003835-Rats,
pubmed-meshheading:15003835-Rats, Wistar,
pubmed-meshheading:15003835-Stress, Physiological,
pubmed-meshheading:15003835-Temperature
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pubmed:year |
2004
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pubmed:articleTitle |
Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons.
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pubmed:affiliation |
Department of Occupational Health, Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, Kadoma 571-0045, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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