|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2004-3-5
|
|
pubmed:abstractText |
The accurate quantification of brain radioactivity concentration is limited by the spatial resolution of the PET scanner for structures smaller than 2-3 times the resolution. In the presence of enlarged cerebrospinal fluid spaces or regions of cortical neuronal loss, a significant underestimation of gray-matter radioactivity concentration due to the resulting partial-volume averaging can potentially occur. To recover the true radioactivity concentration from PET data, algorithms that use the high-resolution anatomic information provided by MRI have been developed. Their effect on PET quantification has been assessed using regions of interest and non-operator-dependent voxel-based analyses such as statistical parametric mapping (SPM), although the mechanisms that lead to an improvement in PET quantification after partial-volume correction (PVC), compared with no PVC, have not been addressed.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
45
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
402-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15001679-Adult,
pubmed-meshheading:15001679-Aged,
pubmed-meshheading:15001679-Aging,
pubmed-meshheading:15001679-Algorithms,
pubmed-meshheading:15001679-Brain,
pubmed-meshheading:15001679-Brain Mapping,
pubmed-meshheading:15001679-Carbon Radioisotopes,
pubmed-meshheading:15001679-Fentanyl,
pubmed-meshheading:15001679-Humans,
pubmed-meshheading:15001679-Image Enhancement,
pubmed-meshheading:15001679-Image Interpretation, Computer-Assisted,
pubmed-meshheading:15001679-Magnetic Resonance Imaging,
pubmed-meshheading:15001679-Male,
pubmed-meshheading:15001679-Middle Aged,
pubmed-meshheading:15001679-Models, Biological,
pubmed-meshheading:15001679-Models, Statistical,
pubmed-meshheading:15001679-Radiopharmaceuticals,
pubmed-meshheading:15001679-Receptors, Opioid, mu,
pubmed-meshheading:15001679-Reproducibility of Results,
pubmed-meshheading:15001679-Sensitivity and Specificity,
pubmed-meshheading:15001679-Subtraction Technique,
pubmed-meshheading:15001679-Tomography, Emission-Computed
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Application of MRI-based partial-volume correction to the analysis of PET images of mu-opioid receptors using statistical parametric mapping.
|
|
pubmed:affiliation |
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Validation Studies
|
