Linked Life Data

15001629

Source:http://linkedlifedata.com/resource/pubmed/id/15001629

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-3-5
pubmed:abstractText
The effect of a 12-wk training program on sc abdominal adipose tissue (SCAAT) was studied in 11 obese women. Before and after the training, biopsies of SCAAT were performed for mRNA levels determination. Using the microdialysis method, involvement of alpha(2)- and beta-adrenergic receptor (ARs) in the control of lipolysis in SCAAT was studied using local perfusion of epinephrine alone or supplemented with phentolamine, an alpha(2)-AR antagonist. In addition, the variation in dialysate glycerol concentrations during exercise (50% peak oxygen consumption at 40 min) in a probe perfused with Ringer's solution was compared with that obtained in a probe perfused with Ringer's solution plus phentolamine. Training did not promote changes in the expression of key genes of the lipolytic pathway. The epinephrine-induced rise in the dialysate glycerol concentration was identical before and after training and was similarly potentiated by phentolamine. During exercise, the potentiating effect of phentolamine on the glycerol response was apparent before, but not after, training. The exercise-induced increase in plasma norepinephrine was lower after training (P = 0.04). In conclusion, training did not modify either the expression of genes involved in the control of lipolysis or alpha(2)- and beta-ARs in situ sensitivity to epinephrine in SCAAT. Training reduced the antilipolytic action of catecholamines mediated by alpha(2)-ARs during exercise, probably due to a reduction of exercise-induced catecholamine increase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1325-31
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15001629-Abdomen, pubmed-meshheading:15001629-Adipose Tissue, pubmed-meshheading:15001629-Adrenergic Agonists, pubmed-meshheading:15001629-Adult, pubmed-meshheading:15001629-Blood Glucose, pubmed-meshheading:15001629-Body Mass Index, pubmed-meshheading:15001629-Epinephrine, pubmed-meshheading:15001629-Fatty Acids, Nonesterified, pubmed-meshheading:15001629-Female, pubmed-meshheading:15001629-Gene Expression, pubmed-meshheading:15001629-Glycerol, pubmed-meshheading:15001629-Humans, pubmed-meshheading:15001629-Insulin, pubmed-meshheading:15001629-Lipolysis, pubmed-meshheading:15001629-Norepinephrine, pubmed-meshheading:15001629-Obesity, pubmed-meshheading:15001629-Oxygen Consumption, pubmed-meshheading:15001629-Physical Endurance, pubmed-meshheading:15001629-RNA, Messenger, pubmed-meshheading:15001629-Receptors, Adrenergic, alpha-2, pubmed-meshheading:15001629-Receptors, Adrenergic, beta, pubmed-meshheading:15001629-Rest, pubmed-meshheading:15001629-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2004
pubmed:articleTitle
Effect of endurance training on adrenergic control of lipolysis in adipose tissue of obese women.
pubmed:affiliation
Franco-Czech Laboratory for Clinical Research on Obesity, French Institute of Health and Medical Research, Institut National de la Santé et de la Recherche Médicale, Unité 586, and Third Faculty of Medicine, Charles University, Prague, Czech Republic.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't