Linked Life Data

14999614

Source:http://linkedlifedata.com/resource/pubmed/id/14999614

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-3-4
pubmed:abstractText
Serotype III group B streptococcus (GBS) causes more invasive disease in infants than do other serotypes in North America. We used multilocus sequence typing to identify clones within 28 invasive serotype III GBS isolates identified from a population-based study and 55 serotype III GBS colonizing isolates from a cohort of women from the same population. Ten allelic sequence types (STs) were identified and primarily involved 2 profiles: ST-19 (57.1% of invasive isolates and 58.2% of colonizing isolates) and ST-17 (32.1% of invasive isolates and 29.1% of colonizing isolates). On concatenation, the 10 allelic profiles converged into 3 groups. Group 1 consisted of ST-19 complex, ST-36, and ST-1, and was closely related to reference genome 2603V/R (serotype V). Group 2 consisted of ST-17 complex. Group 3 consisted of ST-23 complex and was closely related to the serotype III genome strain NEM 316. Neither of the major sequence types or groups was more commonly associated with invasion (P=.61) or with lower levels of maternal capsular polysaccharide-specific IgG (0.89 microg/mL and 0.39 microg/mL, respectively) for ST-19 and ST-17 (P=.86). The close association of genomic strain 2603V/R (serotype V) with ST-19 suggests that the phenomenon of capsule switching may have occurred.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
189
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1097-102
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Multilocus sequence typing of serotype III group B streptococcus and correlation with pathogenic potential.
pubmed:affiliation
Department of Microbiology, and Child Health Research Unit, Alberta Children's Hospital, University of Calgary, Canada. daviesde@msu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't