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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-3-3
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pubmed:abstractText |
Inflammatory bowel disease (IBD) constituting Crohn's disease (CD) and ulcerative colitis (UC) is related to a dysregulated T cell response. CCL20 attracts memory T lymphocytes and dendritic cells. We asked whether CCL20 expression is altered in IBD. Colonic biopsies were obtained from 114 subjects with IBD, non-IBD colitis, irritable bowel syndrome, and healthy controls. CCL20 and CCR6 mRNA expression was measured by Taqman-PCR, and protein secretion from colonic explant cultures (CEC) and its regulation by TNF-alpha by ELISA. CCL20, CCR6, and Langerin were identified by immunohistochemistry and immunofluorescence. CCL20 mRNA and protein were severalfold increased in involved CD and UC but not in non-IBD colitis. TNF-alpha increased and anti-TNF-alpha decreased CCL20 release in healthy control CEC but not in involved IBD colonic specimens. CCL20 localized to follicle-associated epithelium, and CCR6 to the adjacent mantle zone of lymphoid follicles. Furthermore, abundant numbers of Langerin(+) immature dendritic cells were identified in the subepithelial space of IBD specimens. CCL20 might regulate the attraction of T lymphocytes and dendritic cells in IBD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/CCL20 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCR6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CD207 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL20,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose-Binding Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0271-9142
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pubmed:author |
pubmed-author:DunzendorferStefanS,
pubmed-author:EnrichBarbaraB,
pubmed-author:GraslEvelineE,
pubmed-author:GraziadeiIvoI,
pubmed-author:HolzmannSandraS,
pubmed-author:JasarevicZerinaZ,
pubmed-author:KaserArthurA,
pubmed-author:LudwiczekOthmarO,
pubmed-author:MürzlElisabethE,
pubmed-author:MoschenAlexander RAR,
pubmed-author:OffnerFelix AFA,
pubmed-author:RomaniNikolausN,
pubmed-author:TilgHerbertH,
pubmed-author:WeissGünterG,
pubmed-author:WiedermannChristian JCJ
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-85
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14997037-Adult,
pubmed-meshheading:14997037-Antibodies,
pubmed-meshheading:14997037-Antigens, CD,
pubmed-meshheading:14997037-Antigens, Surface,
pubmed-meshheading:14997037-Biopsy,
pubmed-meshheading:14997037-Chemokine CCL20,
pubmed-meshheading:14997037-Chemokines, CC,
pubmed-meshheading:14997037-Colitis, Ulcerative,
pubmed-meshheading:14997037-Crohn Disease,
pubmed-meshheading:14997037-Dendritic Cells,
pubmed-meshheading:14997037-Epithelium,
pubmed-meshheading:14997037-Female,
pubmed-meshheading:14997037-Humans,
pubmed-meshheading:14997037-Lectins, C-Type,
pubmed-meshheading:14997037-Macrophage Inflammatory Proteins,
pubmed-meshheading:14997037-Male,
pubmed-meshheading:14997037-Mannose-Binding Lectins,
pubmed-meshheading:14997037-Middle Aged,
pubmed-meshheading:14997037-RNA, Messenger,
pubmed-meshheading:14997037-Receptors, CCR6,
pubmed-meshheading:14997037-Receptors, Chemokine,
pubmed-meshheading:14997037-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Increased expression of CCL20 in human inflammatory bowel disease.
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pubmed:affiliation |
Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Innsbruck, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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