Linked Life Data

1499687

Source:http://linkedlifedata.com/resource/pubmed/id/1499687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-9-16
pubmed:abstractText
Several age-related phenomena observed at the neuromuscular junction (NMJ) can be viewed as adaptations to cellular deficits. These compensatory mechanisms, which maintain functional and morphologic integrity, are those present in the adult animal. In the study of compensatory mechanisms with age, the choice of an appropriate animal model is important. Three adaptations are discussed: maintenance or increase of transmitter release despite reduced supply of synaptic vesicles; functional reactive sprouting after partial denervation despite reduced axonal transport; and maintenance of nerve terminal integrity in the face of increased outgrowth and retraction. In all cases, successful adaptation in old animals is obtained at the expense of a more fragile system. Either the compensations themselves or the resulting vulnerability may alter the reactions of the aging nervous system to changes in external and internal milieu.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Compensatory plasticity of aging at the neuromuscular junction.
pubmed:affiliation
Department of Neurosciences, Case Western Reserve School of Medicine, Cleveland, Ohio 44106.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review