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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-6-7
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pubmed:abstractText |
Recent studies suggest that vitamin D may play a role in intestinal Na(+)-dependent phosphate transport adaptation to variable levels of dietary P(i). Therefore, the goal of the current study was to assess Na(+)-dependent P(i) cotransport activity in transgenic mice to determine whether vitamin D is an essential mediator of this process. Intestinal brush-border membrane (BBM), Na(+)-dependent P(i) cotransport activity was significantly decreased in vitamin D receptor (VDR) null [VDR (-/-)] mice compared with wild-type (VDR+/+) mice. While intestinal Na-P(i) cotransporter (type IIb) mRNA levels were similar in VDR (-/-) and VDR (+/+) mice, type IIb Na-P(i) cotransporter protein expression was markedly suppressed in VDR (-/-) mice compared with VDR (+/+) mice. Furthermore, Na-P(i) cotransport activity in renal BBM was similar in VDR (-/-) and VDR (+/+) mice, but type IIa Na-P(i) cotransporter protein expression was decreased in VDR (-/-) mice. After administration of a low-P(i) diet, type IIb protein expression was significantly increased in VDR (+/+) and VDR (-/-) mice, and type IIb protein expression was present in the intestinal BBM of VDR (-/-) mice. These data demonstrate that intestinal Na-P(i) cotransport adaptation to a low-P(i) diet occurs independently of vitamin D.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Slc34a1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Slc34a2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin D
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1931-857X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F39-47
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
pubmed-meshheading:14996670-Animals,
pubmed-meshheading:14996670-Diet,
pubmed-meshheading:14996670-Gene Expression Regulation,
pubmed-meshheading:14996670-Genotype,
pubmed-meshheading:14996670-Immunohistochemistry,
pubmed-meshheading:14996670-Mice,
pubmed-meshheading:14996670-Mice, Knockout,
pubmed-meshheading:14996670-Microvilli,
pubmed-meshheading:14996670-Phosphates,
pubmed-meshheading:14996670-Phosphorus, Dietary,
pubmed-meshheading:14996670-Polymerase Chain Reaction,
pubmed-meshheading:14996670-Receptors, Calcitriol,
pubmed-meshheading:14996670-Sodium-Phosphate Cotransporter Proteins,
pubmed-meshheading:14996670-Sodium-Phosphate Cotransporter Proteins, Type IIa,
pubmed-meshheading:14996670-Sodium-Phosphate Cotransporter Proteins, Type IIb,
pubmed-meshheading:14996670-Symporters,
pubmed-meshheading:14996670-Vitamin D
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pubmed:year |
2004
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pubmed:articleTitle |
Intestinal Na-P(i) cotransporter adaptation to dietary P(i) content in vitamin D receptor null mice.
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pubmed:affiliation |
Department of Nutrition, School of Medicine, Tokushima University, Kuramoto-cho 3, Tokushima City 770-8503, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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