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rdf:type |
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lifeskim:mentions |
umls-concept:C0009498,
umls-concept:C0019134,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0023516,
umls-concept:C0032173,
umls-concept:C1280500,
umls-concept:C1522408,
umls-concept:C1697272,
umls-concept:C1704806,
umls-concept:C2004457
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-2
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pubmed:abstractText |
Exposure of blood to artificial surfaces, as in cardiopulmonary bypass, induces an inflammatory response involving complement, leukocyte and platelet activation. To elucidate the specific role of complement in this process, studies were performed on blood circulated in polyvinyl chloride tubing in the absence and presence of complement inhibitors. Parallel experiments were performed with heparin-coated polyvinyl chloride tubing, which is known to prevent complement and cell activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD11b,
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/ITGAD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Lactoferrin,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Polyvinyl Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombospondins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-4975
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
932-41
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14992902-Antigens, CD11,
pubmed-meshheading:14992902-Antigens, CD11b,
pubmed-meshheading:14992902-Cardiopulmonary Bypass,
pubmed-meshheading:14992902-Coated Materials, Biocompatible,
pubmed-meshheading:14992902-Complement Activation,
pubmed-meshheading:14992902-Complement Pathway, Alternative,
pubmed-meshheading:14992902-Complement System Proteins,
pubmed-meshheading:14992902-Flow Cytometry,
pubmed-meshheading:14992902-Heparin,
pubmed-meshheading:14992902-Humans,
pubmed-meshheading:14992902-Immunoenzyme Techniques,
pubmed-meshheading:14992902-Integrin alpha Chains,
pubmed-meshheading:14992902-Lactoferrin,
pubmed-meshheading:14992902-Leukocytes,
pubmed-meshheading:14992902-Models, Biological,
pubmed-meshheading:14992902-Peroxidase,
pubmed-meshheading:14992902-Platelet Activation,
pubmed-meshheading:14992902-Polyvinyl Chloride,
pubmed-meshheading:14992902-Thrombospondins
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pubmed:year |
2004
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pubmed:articleTitle |
Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation.
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pubmed:affiliation |
Department of Medicine, Nordland Hospital, Bodø, and University of Tromsø, Tromsø, Norway. knut.lappegard@nlsh.no
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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