Source:http://linkedlifedata.com/resource/pubmed/id/14992338
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2004-3-2
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pubmed:abstractText |
Previous studies from our laboratory have demonstrated that in an animal model of acute cervical spinal cord injury (SCI), respiratory function can be restored by theophylline. We also have shown that respiratory recovery occurs spontaneously after prolonged postinjury survival periods when a hemidiaphragm is paralyzed by an ipsilateral upper cervical (C2) spinal cord hemisection. Theophylline mediates functional recovery by central nervous system adenosine A1 receptor antagonism; however, it is unclear whether adenosine receptors are altered after prolonged postinjury periods and whether theophylline can further enhance restored respiratory function that occurs spontaneously.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1079-0268
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-71
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14992338-Animals,
pubmed-meshheading:14992338-Diaphragm,
pubmed-meshheading:14992338-Dose-Response Relationship, Drug,
pubmed-meshheading:14992338-Female,
pubmed-meshheading:14992338-Functional Laterality,
pubmed-meshheading:14992338-Gene Expression,
pubmed-meshheading:14992338-Motor Neurons,
pubmed-meshheading:14992338-Neuronal Plasticity,
pubmed-meshheading:14992338-Phosphodiesterase Inhibitors,
pubmed-meshheading:14992338-Phrenic Nerve,
pubmed-meshheading:14992338-RNA, Messenger,
pubmed-meshheading:14992338-Rats,
pubmed-meshheading:14992338-Rats, Sprague-Dawley,
pubmed-meshheading:14992338-Receptor, Adenosine A1,
pubmed-meshheading:14992338-Respiratory Paralysis,
pubmed-meshheading:14992338-Spinal Cord Injuries,
pubmed-meshheading:14992338-Theophylline
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pubmed:year |
2003
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pubmed:articleTitle |
Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection.
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pubmed:affiliation |
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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